About
Element Biosciences is a genomics and multiomics company offering benchtop sequencing platforms engineered to make advanced biological research more accessible, flexible, and cost-effective. Their flagship instruments—AVITI™, AVITI24™, and VITARI™—leverage proprietary Avidite Base Chemistry (ABC™) to deliver highly accurate sequencing results with streamlined workflows. The AVITI24™ is their most advanced system, functioning as the first 5D multiomics platform capable of simultaneous spatial, single-cell, RNA, protein, and morphology profiling within a single 24-hour run. A key innovation is Direct In Sample Sequencing (DISS), which eliminates traditional library preparation steps, reducing complexity and time-to-insight for researchers in cancer, clinical, pharma, and agricultural biology. Supporting their hardware ecosystem, Element offers ElemBio Cloud and ElemBio Catalyst—software solutions that enable data analysis, storage, and collaboration at scale. Their reagent portfolio includes Cloudbreak and Trinity Sequencing Kits, Teton CytoProfiling Kits, and Elevate/Adept Library Adapters. Element Biosciences serves academic research labs, pharmaceutical companies, clinical research organizations, and agricultural bioscience teams seeking to scale sequencing operations without the premium costs associated with traditional platforms. With a 2026 innovation roadmap focused on high-throughput sequencing and expanded spatial capabilities, they position themselves at the frontier of next-generation multiomics.
Key Features
- 5D Multiomics with AVITI24™: Simultaneously profile spatial, single-cell RNA, protein, and cell morphology data in a single 24-hour run on one integrated platform.
- Direct In Sample Sequencing (DISS): Eliminates library prep steps, reducing workflow complexity, sample splitting, and integration issues to accelerate time-to-insight.
- Avidite Base Chemistry (ABC™): Proprietary sequencing chemistry using unique avidites to deliver highly accurate base calls with a low error profile.
- ElemBio Cloud & Catalyst Software: Cloud-based analysis and data management tools for processing, visualizing, and collaborating on sequencing data at scale.
- Scalable Instrument Lineup: A portfolio of instruments—AVITI™, AVITI LT, AVITI24™, and VITARI™—designed to match throughput needs from small labs to high-volume facilities.
Use Cases
- Cancer research labs using AVITI24™ to profile tumor microenvironments with spatial multiomics, revealing resistance mechanisms at subcellular resolution.
- Clinical research organizations running Trinity™ target capture workflows to rethink tumor profiling economics while maintaining high data quality.
- Pharmaceutical companies integrating single-cell RNA and protein co-detection to characterize drug response across complex biological systems.
- Agricultural bioscience teams applying genomic sequencing to improve crop traits, disease resistance, and yield through large-scale DNA/RNA analysis.
- Academic multiomics labs using DISS to streamline workflows, reduce per-sample costs, and increase throughput without sacrificing data depth.
Pros
- No Library Prep Required: DISS technology bypasses traditional library preparation, saving time and reducing technical complexity for researchers.
- Comprehensive Multiomics in One Run: AVITI24™ captures RNA, protein, and morphology simultaneously, delivering richer datasets without running multiple experiments.
- Cost-Effective Scaling: Designed to provide high-throughput sequencing performance without the price premium of legacy platforms, making advanced research more accessible.
- Strong Software Ecosystem: ElemBio Cloud and Catalyst provide integrated data analysis and collaboration tools purpose-built for Element instruments.
Cons
- Enterprise-Level Pricing: As a hardware and reagent company, costs for instruments and consumables are significant, limiting accessibility for smaller labs with tight budgets.
- Specialized Use Case: Primarily suited for genomics and life sciences research; not applicable to general AI or software-focused workflows.
- Hardware Dependency: Software capabilities are tied to proprietary instruments, so users cannot run analyses independently of Element hardware.
Frequently Asked Questions
What is the AVITI24™ platform?
AVITI24™ is Element Biosciences' most advanced sequencing system, offering 5D multiomics capabilities that simultaneously capture spatial, single-cell RNA, protein, and morphology data in a single 24-hour run over a 20 cm² imaging area.
What is Direct In Sample Sequencing (DISS)?
DISS is a workflow innovation that allows researchers to sequence directly from a sample without traditional library preparation, eliminating sample splitting, reducing integration complexity, and accelerating results.
What software tools does Element Biosciences offer?
Element offers ElemBio Cloud for cloud-based data storage and analysis, and ElemBio Catalyst for deeper bioinformatics workflows, both designed to work natively with their sequencing platforms.
Who is Element Biosciences designed for?
Their platforms serve academic research labs, pharmaceutical companies, clinical research organizations, and agricultural bioscience teams that need scalable, high-accuracy genomic and multiomic sequencing.
What makes ABC™ Chemistry different from other sequencing chemistries?
Avidite Base Chemistry (ABC™) uses proprietary avidite molecules that bind to target sequences with high specificity, delivering superior base-call accuracy and enabling reliable, reproducible sequencing results.
