About
Standard BioTools is a life sciences company providing leading genomic and proteomic research platforms designed for translational and clinical researchers who need reproducible, high-quality biological data. Their flagship product lines include the CyTOF XT (mass cytometry for intracellular protein detection), Hyperion XTi (imaging mass cytometry for spatial biology), and Biomark X9 (high-throughput genomic profiling). These systems enable discovery across research areas such as oncology, immunology, neuroscience, infectious disease, pharmacogenomics, and agrigenomics. Standard BioTools also offers a rich ecosystem of consumables, pre-validated panels, custom reagents, and lyophilized assay kits like LyoMax Panels for stable high-volume studies. Researchers benefit from software tools including the CyTOF Panel Designer, D3 Assay Design, and comprehensive bioinformatics resources. Lab Services provide project-level support from sample prep to data analysis. The platform is particularly valued for immune profiling, biomarker discovery, single-cell multi-omics, and same-slide omics workflows. With an extensive resource library including publications, webinars, application notes, and imaging datasets, Standard BioTools supports researchers at every stage of discovery.
Key Features
- CyTOF Mass Cytometry: High-parameter single-cell protein detection enabling simultaneous measurement of 40+ markers per cell for deep immune and cellular profiling.
- Hyperion Imaging Mass Cytometry: Spatial proteomics platform combining high-resolution imaging with mass cytometry for functional profiling of tissue architecture in situ.
- Biomark Genomic Profiling: High-throughput multi-assay genomic system for gene expression, genotyping, sample multiplexing, and pathogen detection in a single run.
- Panel Designer & Custom Assays: Software-guided panel design tools and D3 custom assay design service to help researchers build optimized, reproducible experimental workflows.
- End-to-End Lab Services: Comprehensive laboratory support services covering sample preparation, assay execution, and data analysis for any research project scale.
Use Cases
- Immune cell profiling in oncology and immunotherapy research using high-parameter CyTOF mass cytometry
- Spatial mapping of tumor microenvironments with Hyperion Imaging Mass Cytometry to understand cell-cell interactions in tissue context
- High-throughput genotyping and gene expression profiling across large patient cohorts with the Biomark X9 system
- Biomarker discovery and validation for clinical trials leveraging standardized, reproducible CyTOF panel workflows
- Infectious disease and pathogen detection research using multiplex genomic assays for rapid, scalable sample analysis
Pros
- Best-in-class reproducibility: Platforms are trusted by clinical and translational researchers for consistent, high-quality data generation across multi-site and high-volume studies.
- Comprehensive ecosystem: Offers instruments, reagents, pre-validated panels, custom assays, software, and lab services in one integrated portfolio.
- Broad research application coverage: Supports diverse research areas including oncology, immunology, neuroscience, infectious disease, and agrigenomics with specialized solutions.
Cons
- High cost of entry: CyTOF and Hyperion instrumentation requires significant capital investment, limiting accessibility for smaller labs or early-stage startups.
- Steep learning curve: Platforms require specialized training and expertise in mass cytometry and bioinformatics to generate and interpret high-dimensional data.
Frequently Asked Questions
What is CyTOF technology?
CyTOF (Cytometry by Time-Of-Flight) is a mass cytometry platform that uses metal-tagged antibodies to simultaneously measure 40+ protein markers at the single-cell level, enabling deep immune and cellular profiling without spectral overlap limitations.
What is Imaging Mass Cytometry (IMC)?
Imaging Mass Cytometry, powered by the Hyperion platform, combines laser ablation with mass cytometry to spatially resolve protein expression within tissue sections, preserving tissue architecture while profiling dozens of markers simultaneously.
What research areas does Standard BioTools support?
Standard BioTools supports oncology, immunology, neuroscience, infectious disease, pharmacogenomics, agrigenomics, biomarker discovery, and clinical translational research, among others.
Does Standard BioTools offer custom assay design?
Yes. Their D3 Assay Design service provides expert-supported custom genomic assay development, and the CyTOF Panel Designer software helps researchers build and optimize antibody panels for their specific research needs.
What are LyoMax Panels?
LyoMax Panels are lyophilized (dry-format) CyTOF assay kits that offer improved stability and faster sample processing, making them ideal for high-volume studies and labs requiring standardized, ready-to-use workflows.
