About
Synthego is a pioneering biotechnology company that delivers comprehensive CRISPR gene editing and molecular diagnostics solutions for the life sciences industry. Their product portfolio spans synthetic guide RNAs (sgRNAs), engineered nucleases (including SpCas9 and the high-fidelity hfCas12Max), base editors (AccuBase CBE), and GMP-grade CRISPR components for therapeutic manufacturing. Researchers and clinicians can leverage Synthego's reagents for a wide range of applications including cell and gene therapy development, CAR-T cell engineering, iPSC genome editing, and CRISPR-based diagnostics. On the molecular biology side, Synthego supplies isothermal amplification kits (RPA/RT-RPA), PCR and RT enzymes, IVT enzymes such as T7 Polymerase for mRNA therapeutics, and cell-free protein expression systems. For analysis and design, their ICE CRISPR Analysis Tool provides computational support for editing efficiency assessment. Synthego also supports GMP manufacturing with cGMP-grade gRNA and CRISPR editors, regulatory expertise, and IND submission support—having cleared over 14 INDs with 40+ successful customer audits. Their platform serves academic researchers, biotech startups, and large pharmaceutical enterprises looking to accelerate cell and gene therapy programs from bench to clinic.
Key Features
- Research & GMP-Grade CRISPR Reagents: Offers a full range of synthetic guide RNAs, SpCas9, hfCas12Max, and base editors in both research and cGMP-certified formats for therapeutic development.
- ICE CRISPR Analysis Tool: A computational tool for analyzing CRISPR editing efficiency, helping researchers quantify and interpret genome editing outcomes from sequencing data.
- Molecular Diagnostics Reagents: Provides isothermal amplification kits (RPA/RT-RPA), IVT enzymes, and PCR products to support rapid nucleic acid detection and diagnostic assay development.
- IND Submission & Regulatory Support: Supports customers through the regulatory process with 14+ cleared INDs and 40+ successful audits, offering documentation and GMP manufacturing expertise.
- mRNA Therapeutics Enablement: Engineered T7 Polymerase and IVT enzyme kits generate high yields of RNA, supporting the development of mRNA-based therapies and vaccines.
Use Cases
- Developing CRISPR-based cell and gene therapies using GMP-grade guide RNAs and nucleases with IND submission support.
- Engineering CAR-T cells or iPSC-derived cell lines for oncology or regenerative medicine research.
- Building rapid nucleic acid diagnostic assays using RPA/RT-RPA isothermal amplification kits and CRISPR detection components.
- Producing mRNA therapeutics or vaccines using high-yield T7 Polymerase and IVT enzyme systems.
- Analyzing CRISPR genome editing outcomes in research workflows using the ICE CRISPR Analysis Tool.
Pros
- Research-to-Clinic Continuum: Provides both research-grade and GMP-grade products under one roof, enabling seamless scale-up from early discovery to clinical manufacturing.
- Proven Regulatory Track Record: With 14+ cleared INDs and 40+ customer audits, Synthego has demonstrated reliability in supporting therapeutic programs through regulatory milestones.
- Comprehensive Product Portfolio: Covers CRISPR editing, base editing, molecular diagnostics, and mRNA tools, reducing the need for multiple vendors across complex workflows.
Cons
- Pricing Not Publicly Listed: Product pricing requires direct contact or account login, which creates friction for new users evaluating cost-effectiveness upfront.
- Highly Specialized Audience: The platform is designed for trained molecular biology researchers and clinicians; it is not accessible to general users or non-specialists.
- Geography-Restricted Ordering: In some regions, orders must be placed through a local distributor rather than directly through the website, adding logistical complexity.
Frequently Asked Questions
What types of CRISPR products does Synthego offer?
Synthego offers synthetic guide RNAs (sgRNAs), SpCas9 and hfCas12Max nucleases, AccuBase cytosine base editors, and GMP-grade versions of these products for clinical and therapeutic applications.
Does Synthego support GMP manufacturing for therapeutics?
Yes. Synthego provides cGMP-grade gRNA and CRISPR editors, along with regulatory expertise and IND submission support. They have cleared over 14 INDs and passed 40+ customer audits.
What is the ICE CRISPR Analysis Tool?
ICE (Inference of CRISPR Edits) is a free computational tool from Synthego that analyzes Sanger sequencing data to quantify CRISPR editing efficiency and identify indel patterns at a target locus.
What molecular diagnostics products does Synthego provide?
Synthego offers RPA and RT-RPA kits for isothermal amplification, IVT enzymes including T7 Polymerase, PCR and RT enzymes, and sample preparation tools for building rapid nucleic acid diagnostic assays.
Who are Synthego's primary customers?
Synthego serves academic researchers, biotech startups, and large pharmaceutical and diagnostics companies that require high-quality CRISPR reagents and molecular biology tools for both research and clinical development.
