Ultima Genomics

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Ultima Genomics provides the UG200™ Series sequencing platform for population-scale genomics, offering 60,000+ genomes per year with superior accuracy and flexibility.

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About

Ultima Genomics is redefining the genomics landscape with its next-generation sequencing architecture, purpose-built for population-scale research and clinical applications. At the heart of its offering is the UG200™ Series—available in single-wafer and dual-wafer (Ultra) configurations—which delivers up to 20 billion reads per wafer and supports up to 60 automated runs per week with single-shift operation, exceeding 60,000 genomes per year. The platform replaces traditional emulsion PCR with rapid isothermal amplification, enabling seamless integration with existing lab automation workflows. Improved variant calling accuracy ensures superior coverage uniformity across high-GC and structurally complex genomic regions, critical for oncology and germline applications. Ultima's Solaris 2.0 library preparation workflows offer flexibility and ease of use, with compatibility for leading third-party library prep providers. An open ecosystem approach allows researchers to choose the tools and workflows best suited to their needs. For data analysis, Ultima provides pre-configured secondary analysis pipelines and a dedicated high-performance server optimized for its sequencing data. Focus areas include whole genome sequencing, minimal residual disease detection in oncology, methylation profiling, single-cell sequencing, proteomics, and transcriptomics. Ultima Genomics is an ideal solution for genomics centers, pharma companies, academic research institutions, and clinical labs seeking to scale their sequencing output without sacrificing accuracy or flexibility.

Key Features

UG200™ Series High-Throughput Sequencing: Supports up to 20B reads per wafer and 60+ automated runs per week, enabling more than 60,000 genomes per year with two instrument configurations (single and dual wafer).
Rapid Isothermal Amplification: Replaces traditional emulsion PCR with isothermal amplification for seamless integration with existing laboratory automation infrastructure.
Advanced Variant Calling Accuracy: Delivers improved variant detection and coverage uniformity across high-GC content and structurally complex genomic regions critical to oncology and germline workflows.
Solaris 2.0 Library Prep Workflows: Flexible, easy-to-use library preparation workflows compatible with leading third-party providers, supporting an open and collaborative ecosystem.
Pre-Configured Bioinformatics Pipelines: Includes optimized secondary analysis pipelines and a dedicated high-performance server for efficient, robust analysis of Ultima Genomics sequencing data.

Use Cases

Population-scale whole genome sequencing for large clinical or research cohorts exceeding tens of thousands of samples per year.
Liquid biopsy and minimal residual disease detection in oncology through high-sensitivity SNV calling from cell-free DNA.
Genome-wide methylation profiling for epigenomic research and cancer biomarker discovery.
High-depth single-cell sequencing experiments to study gene expression, chromatin accessibility, and cellular heterogeneity.
Proteomics and transcriptomics studies at population scale, enabling discovery of differential gene expression and protein abundance patterns.

Pros

Exceptional Throughput at Scale: The UG200 Series can process over 60,000 genomes annually, making it one of the highest-throughput sequencing solutions available for large cohort studies.
Open Ecosystem Compatibility: Supports third-party library prep providers and integrates with existing lab automation, reducing vendor lock-in and increasing workflow flexibility.
Multi-Application Versatility: Covers a broad range of genomics applications including germline WGS, liquid biopsy, single-cell sequencing, epigenomics, proteomics, and transcriptomics in one platform.
Compact and Efficient Design: Delivers twice the output of comparable platforms with half the physical footprint, optimizing lab space and operational efficiency.

Cons

Enterprise-Level Cost: As a premium sequencing hardware platform, Ultima Genomics is primarily accessible to well-funded research institutions, genomics centers, and pharmaceutical companies.
Requires Specialized Infrastructure: Deploying and operating the UG200 Series requires dedicated lab infrastructure, trained personnel, and IT resources for bioinformatics pipeline management.
Limited Public Pricing Transparency: Pricing and procurement details are not publicly listed, requiring direct engagement with a sales specialist, which may slow down evaluation for smaller organizations.

Frequently Asked Questions

The UG200™ Series is Ultima Genomics' latest high-throughput DNA sequencing platform, available in single-wafer and dual-wafer (Ultra) configurations. It can produce up to 20 billion reads per wafer and perform over 60 automated runs per week, supporting more than 60,000 genomes per year.

Ultima Genomics supports a wide range of genomics applications including whole genome sequencing (germline), oncology (liquid biopsy and minimal residual disease), epigenomics (methylation profiling), single-cell sequencing, proteomics, and RNA/transcriptomics analysis.

Yes. The Solaris 2.0 library preparation workflows are designed to be compatible with leading third-party library prep providers, and Ultima supports an open ecosystem that allows researchers to choose the tools best suited to their workflows.

Each Ultima Genomics sequencing platform includes a dedicated high-performance server and a suite of pre-configured secondary analysis pipelines optimized for Ultima data, enabling efficient and robust downstream genomic analysis.

Ultima Genomics is designed for genomics research centers, academic institutions, pharmaceutical companies, clinical laboratories, and any organization conducting large-scale sequencing projects that demand high throughput, accuracy, and cost efficiency.